PXD069002-1

PXD069002 is an original dataset announced via ProteomeXchange.

Title	Genome-scale Metabolic Modeling of the Priority Fungal Pathogen Lichtheimia corymbifera
Description	Fungi harbor unique primary and secondary metabolic pathways that represent a hidden treasure of biochemical and natural compounds. Their metabolism is central to their ability to interact with, to adapt to and to survive in host environments, and also to cause human disease and great harm. Among those, Lichtheimia corymbifera whose emergence as causative agent of mucormycosis prompted (i) its classification to the high priority fungal pathogens by the World Health Organization and (ii) its increasing importance as model organism for the study of invasive fungal infections. We reconstructed a genome-scale L. corymbifera metabolic model and show substantial differential metabolic activity down to pathway and reaction level to process carbohydrate or amino acid carbon sources. We furthermore adapt the model to proteome changes depending on human leukocyte presence and show fungal sphingolipid metabolic activity changes next to changes in cytoskeleton and tight junction associated leukocyte activity over three days of cultivation. These insights underline the possibility that L. corymbifera can potentially scavenge host-derived lipids to fortify its own cell membrane. We demonstrate that in silico metabolic predictions can provide testable hypotheses and can lead to the identification of metabolic processes which are essential for the development of targeted antifungal drugs and novel solutions for balancing host challenges.
HostingRepository	PRIDE
AnnounceDate	2026-07-08
AnnouncementXML	Submission_2026-07-07_18:11:53.012.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD069002
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Thomas Krüger
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Lichtheimia corymbifera JMRC:FSU:9682; NCBI TaxID: NEWT:1263082;
ModificationList	phosphorylated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-30 07:14:00	ID requested
⏵ 1	2026-07-07 18:11:53	announced

10.6019/PXD069002;

10.1093/FEMSML/UQAG025;

submitter keyword: Lichtheimia corymbifera, genome-scale metabolic model, fungal pathogenicity

Axel A. Brakhage
contact affiliation	Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology / Hans Knöll Institute Jena (Leibniz-HKI), Jena, Germany
contact email	axel.brakhage@leibniz-hki.de
lab head
Thomas Krüger
contact affiliation	Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute
contact email	thomas.krueger@leibniz-hki.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD069002

PRIDE project URI

• PRIDE
  1. PXD069002
     1. Label: PRIDE project
     2. Name: Genome-scale Metabolic Modeling of the Priority Fungal Pathogen Lichtheimia corymbifera