PXD068929-1

PXD068929 is an original dataset announced via ProteomeXchange.

Title	Lignans redress autoimmunity and achieve curative effects on myasthenia gravis by ameliorating the gut ecology
Description	Myasthenia gravis (MG) is a serious inflammatory autoimmune disease with continuous production of autoantibodies against targets in the neuromuscular junctions, resulting in muscle weakness. Autoimmunity has long been presumed to be irreversible. The current therapeutic regimens do not always provide ideal treatment. Previously, we established that lignans could effectively inhibit inflammatory and malignant conditions including cancer. In this study, we used a mouse MG model with R97-116 peptide as the antigen to evaluate the effects of lignans on MG and investigate the molecular mechanisms of effects by multi-omics analyses. Lignans markedly alleviated muscle atrophy and elevated muscle strength. The gut microbiome composition was profoundly remodeled, the gut barrier was significantly ameliorated, and the levels of the anti-R97-116 IgG autoantibody were radically lowered, all signs suggesting reversed conditions of MG by lignans. Fecal microbiota transplantation experiments provided further evidence to validate roles of the gut microbiome in mediating the curative effects of lignans on MG. Mechanistically, the curative effects were associated with the inhibition of the Rap1gds1/Cdc42 signaling pathway.
HostingRepository	iProX
AnnounceDate	2025-09-29
AnnouncementXML	Submission_2026-08-31_01:23:28.384.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiawei Zhang
SpeciesList	scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-29 00:05:58	ID requested
⏵ 1	2026-08-31 01:23:28	announced

Dataset with its publication pending

submitter keyword: Lignans redress autoimmunity and achieve curative effects on myasthenia gravis by ameliorating the gut ecology

Shulin Liu
contact affiliation	Harbin Medical University
contact email	3367912143@qq.com
lab head
Jiawei Zhang
contact affiliation	Harbin Medical University
contact email	17861171192@163.com
dataset submitter

iProX dataset URI