PXD068786 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | TMT-Based Quantitative Proteomic Profiling of DNASE1L3-Deficient and Wild-Type Mouse Livers |
| Description | This study investigates the impact of DNASE1L3 deficiency on hepatic immune–metabolic homeostasis using TMT-based quantitative proteomics. Liver tissues from 8-week-old wild-type (WT) and DNASE1L3 knockout (KO) mice were analyzed by LC-MS/MS. Differential protein expression and pathway enrichment analyses revealed alterations in lipid metabolism, oxidative stress, Kupffer cell polarization, and ferroptosis, supporting a role for DNASE1L3 in regulating hepatic immune–metabolic stability. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-17 |
| AnnouncementXML | Submission_2025-11-17_10:33:55.575.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD068786 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | liangchen lei |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; methylthiolated residue; acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-24 14:50:30 | ID requested | |
| ⏵ 1 | 2025-11-17 10:33:56 | announced | |
Publication List
Keyword List
| submitter keyword: proteomics, TMT, ferroptosis, liver, Kupffer cells,DNASE1L3, LC-MS/MS, NAFLD |
Contact List
| Quanyan Liu |
|---|
| contact affiliation | Department of Hepatology, Tianjin Medical University General Hospital, Tianjin, China |
| contact email | liuqy@tmu.edu.cn |
| lab head | |
| liangchen lei |
|---|
| contact affiliation | Tianjin Medical University General Hospital |
| contact email | leiliangchen@163.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD068786 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068786
- Label: PRIDE project
- Name: TMT-Based Quantitative Proteomic Profiling of DNASE1L3-Deficient and Wild-Type Mouse Livers
