PXD068785-1

PXD068785 is an original dataset announced via ProteomeXchange.

Title	The Role of FASN in bladder cancer
Description	To dissect the mechanistic interplay between fatty acid metabolism and cigarette smoke–induced signaling in bladder cancer, we employed a proteomics analysis xenograft tumors derived from the UMUC3 with either stable FASN knockdown (KD) or control shRNA, with and without cigarette smoke. We performed global proteomics and phospho proteomics analysis to characterize the molecular alterations associated with FASN KD up on smoke exposure.
HostingRepository	PRIDE
AnnounceDate	2026-06-15
AnnouncementXML	Submission_2026-06-14_17:12:50.010.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Antrix Jain
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	phosphorylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-24 14:09:48	ID requested
⏵ 1	2026-06-14 17:12:50	announced

10.1016/j.canlet.2026.218562;

Amara CS, Piyarathna DWB, Kamal AHM, Chan YS, Kami Reddy KR, Ambati CSR, Hassan MK, Shriwas P, Gandhi T, Jain A, Gangnus T, Popli P, Borkar R, Kang SW, Summers SL, Putluri V, Grimm SL, Venkatesh S, Song N, Seeley EH, Hedlich-Dwyer J, Chen SH, Mahajan NP, Jain AK, Dobrolecki LE, Wells GA, Villanueva H, Li J, Liu X, Bollag RJ, Malovannaya A, Jung SY, Lee HS, Asangani IA, Terris MK, Creighton CJ, Ballester LY, Karanam B, Liu S, Lee M, Raju RR, Siddiqui MM, Eberlin LS, Kommagani R, Sreekumar A, Gao J, Young NL, Hodges HC, Coarfa C, Gassman NR, Lerner SP, Lotan Y, Putluri N, Cigarette smoke induces FASN-dependent fatty acid metabolic rewiring to drive bladder cancer progression. Cancer Lett, 653():218562(2026) [pubmed]

submitter keyword: proteomics, FASN, cigarette smoke,Bladder cancer

Putluri Nagireddy
contact affiliation	Baylor College of Medicine
contact email	putluri@bcm.edu
lab head
Antrix Jain
contact affiliation	Baylor College of Medicine
contact email	antrixj@bcm.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD068785

PRIDE project URI

• PRIDE
  1. PXD068785
     1. Label: PRIDE project
     2. Name: The Role of FASN in bladder cancer