PXD068756-1

PXD068756 is an original dataset announced via ProteomeXchange.

Title	FAM64A promoted aggressiveness and chemoresistance in colorectal cancer cells by lipogenesis or Akt pathway
Description	This dataset was generated based on the hypothesis that FAM64A promotes colorectal cancer aggressiveness by reprogramming the cellular proteome. Quantitative proteomic analysis was performed by LC-MS/MS on three groups of SW480 cells: the FAM64A overexpression group, the FAM64A knockdown group, and the control group. The data showed that FAM64A not only significantly changed the abundance of proteins associated with cell proliferation and invasion but also drove the reprogramming of proteins related to lipid and carbohydrate metabolism. Therefore, these findings provide a molecular mechanism to explain how FAM64A promotes cancer progression. This data is of great value as it can be used to further mine biomarkers, study tumor metabolism, or construct signaling networks.
HostingRepository	iProX
AnnounceDate	2025-09-24
AnnouncementXML	Submission_2025-12-31_00:29:02.680.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lingling Wang
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-23 23:33:56	ID requested
⏵ 1	2025-12-31 00:29:03	announced

Dataset with its publication pending

submitter keyword: colorectal cancer, FAM64A, aggressiveness, lipogenesis, Akt signal pathway, target therapy

Huachuan Zheng
contact affiliation	The First Affiliated Hospital of Jinzhou Medical University
contact email	zheng_huachuan@hotmail.com
lab head
Lingling Wang
contact affiliation	The Affiliated Hospital of Chengde Medical University
contact email	690750933@qq.com
dataset submitter

iProX dataset URI