PXD068718-1
PXD068718 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Adipocyte-Specific TMEM41B Deficiency Enhances Bone Formation and Attenuates Osteoporosis via the YY1-Calreticulin Axis |
| Description | Osteoporosis (OP) is a prevalent skeletal disorder characterized by excessive bone marrow adiposity and impaired osteogenesis. Here, we identify TMEM41B, an endoplasmic reticulum-resident protein, as a critical regulator of bone homeostasis through its actions in bone marrow adipocytes (BMAs). Adipocyte-specific deletion of TMEM41B in mice (TMEM41B AKO) significantly increased bone mass, improved trabecular and cortical bone parameters, and enhanced mechanical strength, particularly in long bones. |
| HostingRepository | iProX |
| AnnounceDate | 2025-09-23 |
| AnnouncementXML | Submission_2025-09-22_20:14:41.150.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hui Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-09-22 20:14:08 | ID requested | |
| ⏵ 1 | 2025-09-22 20:14:41 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Bone |
Contact List
| Tiemin Liu | |
|---|---|
| contact affiliation | Fudan University |
| contact email | tiemin_liu@fudan.edu.cn |
| lab head | |
| Hui Wang | |
| contact affiliation | Fudan University |
| contact email | tangguodidi222@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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