PXD068695 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Characterization of MS white matter derived extracellular vesicles |
| Description | This dataset contains proteomic profiles of extracellular vesicles (EVs) isolated from human multiple sclerosis (MS) white matter tissue, alongside the corresponding tissue proteome. The aim of this study is to characterize the protein cargo of MS-derived EVs compared to bulk tissue and to identify molecular features linked to MS pathology. Proteins were labeled using TMTpro 18-plex reagents, fractionated by basic pH reversed-phase LC, and analyzed by Orbitrap Fusion Lumos mass spectrometry. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-17 |
| AnnouncementXML | Submission_2025-11-16_16:34:52.122.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Larissa Jank |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | TMT6plex-126 reporter+balance reagent acylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-22 11:37:30 | ID requested | |
| ⏵ 1 | 2025-11-16 16:34:53 | announced | |
Publication List
| 10.1002/jev2.70197; |
| Jank L, Kumar MKS, Ryu T, Thapa R, Gololobova O, Niepokny TD, Calabresi PA, Witwer K, Dutta R, Na CH, Bhargava P, Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation. J Extracell Vesicles, 14(11):e70197(2025) [pubmed] |
Keyword List
| submitter keyword: Human Brain |
Contact List
| Pavan Bhargava |
|---|
| contact affiliation | Department of Neurology, Johns Hopkins University School of Medicine |
| contact email | pbharga2@jhmi.edu |
| lab head | |
| Larissa Jank |
|---|
| contact affiliation | Johns Hopkins University |
| contact email | ljank1@jhmi.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD068695 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068695
- Label: PRIDE project
- Name: Characterization of MS white matter derived extracellular vesicles
