PXD068681-1

PXD068681 is an original dataset announced via ProteomeXchange.

Title	Alzheimer’s disease risk and the isoform dependence of phospholipid-apolipoprotein E interaction
Description	The ε4 allele of the APOE gene, encoding the E4 isoform of apolipoprotein E, is the leading genetic risk factor for late-onset Alzheimer’s disease. While many potential mechanisms have been proposed to explain this risk, no dominant or unifying process has yet emerged. Here, we explore the primary function of apolipoprotein E in lipid transport and metabolism, by examining its lipid association properties, to establish whether they show isoform dependence and thereby could mediate Alzheimer’s risk. We focus on ethanolamine plasmalogen, a phospholipid subclass known to be depleted in Alzheimer’s disease brain.
HostingRepository	PRIDE
AnnounceDate	2026-03-09
AnnouncementXML	Submission_2026-03-08_21:51:50.645.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jenny Hallqvist
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Synapt MS

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-22 05:43:03	ID requested
⏵ 1	2026-03-08 21:51:51	announced

10.1093/braincomms/fcag040;

H, ä, llqvist J, Taanman JW, G, ö, teson A, Heywood WE, Schott JM, Hardy J, Land, é, n M, Zetterberg H, Mills K, Ginsberg L, Plasmalogen deficiency and the Alzheimer's disease risk of apolipoprotein E4. Brain Commun, 8(1):fcag040(2026) [pubmed]

submitter keyword: CSP, proteomics, MS, ApoE, lipids, plasmalogen

Kevin Mills
contact affiliation	UCL Centre for Inborn Errors of Metabolism, Great Ormond Street Institute of Child Health
contact email	kevin.mills@ucl.ac.uk
lab head
Jenny Hallqvist
contact affiliation	University College London
contact email	j.hallqvist@ucl.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD068681

PRIDE project URI

• PRIDE
  1. PXD068681
     1. Label: PRIDE project
     2. Name: Alzheimer’s disease risk and the isoform dependence of phospholipid-apolipoprotein E interaction