PXD068613 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomics analysis of Vitamin C in people with type 2 diabetes |
| Description | A double-blind, placebo-controlled, cross-over trial was undertaken in people with T2D, who were administered 1000mg/day ascorbic acid or placebo for 4-months. Plasma proteins in 26 participants (22 male, 4 female, age 62.6±6.5 years, HbA1c 7.6±0.7%) were quantified by liquid chromatography/mass spectrometry with data independent acquisition. Differential protein expression was assessed for: VC post-supplementation vs. placebo post-supplementation; and VC post-supplementation vs. control [pooling of all non-active conditions]. Pathway enrichments were explored, and correlations between differentially expressed proteins and significantly improved clinical outcomes were assessed. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-07-02 |
| AnnouncementXML | Submission_2026-07-02_01:52:12.058.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shaun Mason |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-20 23:43:52 | ID requested | |
| ⏵ 1 | 2026-07-02 01:52:13 | announced | |
Publication List
| 10.1038/s41387-026-00447-5; |
| Van Grunsven T, Wadley GD, Mason SA, Plasma proteomics analysis of vitamin C supplementation in people with type 2 diabetes. Nutr Diabetes, ():(2026) [pubmed] |
Keyword List
| submitter keyword: proteomics,type 2 diabetes, ascorbic acid, vitamin C, clinical trial |
Contact List
| Shaun Mason |
|---|
| contact affiliation | Deakin University |
| contact email | s.mason@deakin.edu.au |
| lab head | |
| Shaun Mason |
|---|
| contact affiliation | Deakin University |
| contact email | s.mason@deakin.edu.au |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/07/PXD068613 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068613
- Label: PRIDE project
- Name: Proteomics analysis of Vitamin C in people with type 2 diabetes
