PXD068594 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Profiling of activated RBR E3 ligases using E2V derived activity-based probes |
| Description | Structure-based E2 enzyme variants (E2Vs) were used to create biotinylated activity-based probes use as handles for affinity purification-mass spectrometry to identify interacting E3s. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-05 |
| AnnouncementXML | Submission_2026-01-05_02:14:52.987.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Gisele Andree |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | timsTOF Pro 2 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-19 13:37:25 | ID requested | |
| ⏵ 1 | 2026-01-05 02:14:54 | announced | |
Publication List
| Du J, Andree GA, Horn-Ghetko D, Stier L, Singh J, Kostrhon S, Kiss L, Mann M, Sidhu SS, Schulman BA, E2 variants for probing E3 ubiquitin ligase activities. Proc Natl Acad Sci U S A, 123(1):e2524899122(2026) [pubmed] |
| 10.1073/pnas.2524899122; |
Keyword List
| submitter keyword: E2 enzyme,E3 ligase, activity-based probe |
Contact List
| Brenda Schulman |
|---|
| contact affiliation | Department of Molecular Machines and Signaling, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany |
| contact email | schulman@biochem.mpg.de |
| lab head | |
| Gisele Andree |
|---|
| contact affiliation | MPIB |
| contact email | andree@biochem.mpg.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD068594 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068594
- Label: PRIDE project
- Name: Profiling of activated RBR E3 ligases using E2V derived activity-based probes
