PXD068576-1

PXD068576 is an original dataset announced via ProteomeXchange.

Title	LMO2/LDB1 protein complex in AML cells
Description	These are raw mass spectrometry data discussed in our paper: “The LMO2-LDB1-TAL1 complex regulates transcription networks in AML”, where we implicate this multisubunit complex as a key regulator of leukemia cell transcription. The key method was affinity purification followed by tandem mass spectrometry. The LDB1 and LMO2 proteins were FLAG tagged and encoding cDNAs were cloned into lentiviral expression vectors allowing transduction of leukemia cells. Protein purification and MS/MS are described below.
HostingRepository	PRIDE
AnnounceDate	2026-02-09
AnnouncementXML	Submission_2026-02-08_16:15:46.718.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Utpal Dave
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-19 07:40:52	ID requested
⏵ 1	2026-02-08 16:15:50	announced

Dunham N, Wang Z, Neelamraju Y, Guo Y, Paudel BB, Meydan C, Gandara JA, Abdelmalak FA, Fan H, Hardwick J, Layer JH, Lee T, Maier B, McDonald WH, Patnaik I, Prajapati S, Rapaport F, Sheridan C, Sheynkman G, Zumbo P, Becker MW, Bullinger L, Carroll MP, D'Andrea RJ, Dillon R, Levine RL, Mason CE, Melnick AM, Neuberg DS, Bekiranov S, Zang C, Dav, é UP, Garrett-Bakelman FE, The LMO2-LDB1-TAL1 complex regulates transcription networks in acute myeloid leukemia. Blood Neoplasia, 3(1):100186(2026) [pubmed]

10.1016/j.bneo.2025.100186;

submitter keyword: complexes, immunoprecipitation,human

Utpal Dave
contact affiliation	Indiana University School of Medicine
contact email	udave@iu.edu
lab head
Utpal Dave
contact affiliation	Indiana University School of Medicine
contact email	udave@iu.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD068576

PRIDE project URI

• PRIDE
  1. PXD068576
     1. Label: PRIDE project
     2. Name: LMO2/LDB1 protein complex in AML cells