PXD068489-1

PXD068489 is an original dataset announced via ProteomeXchange.

Title	A landscape analysis of human SUMOylation: A comprehensive meta-analysis of publicly available datasets
Description	SUMOylation is an important but understudied post-translational modification (PTM) linked to diverse physiological and pathological processes. Various laboratories have developed protocols for identifying SUMOylation target sites using SUMO enrichment followed by mass spectrometry. As part of the PTMeXchange consortium, our group has developed tools and statistical approaches for robust PTM meta-analysis. Here, we present a comprehensive human SUMOylation reference “build,” encompassing 35,721 sites on 6,146 proteins classified into three confidence tiers. SUMOylated lysines were enriched in intrinsically disordered regions and underrepresented in tightly packed structures. Sites frequently colocalized with proximal phosphosites and were enriched for disease-associated genetic variants. Motif analysis revealed canonical, inverted, and novel motifs that connect SUMOylation to processes such as chromatin remodeling, histone modification, and mRNA processing. To support widespread use, for example, in training artificial intelligence algorithms, the build has been deposited in multiple resources to support different user groups - PRIDE, UniProtKB, and PeptideAtlas.
HostingRepository	PRIDE
AnnounceDate	2025-12-16
AnnouncementXML	Submission_2025-12-16_09:07:03.162.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD068489
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Yasset Perez-Riverol
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: NCBITaxon:9606;
ModificationList	phosphorylated residue; sumoylated lysine
Instrument	Q Exactive HF-X; Q Exactive; LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-18 07:34:49	ID requested
⏵ 1	2025-12-16 09:07:03	announced

10.6019/PXD068489;

submitter keyword: None

Andrew R Jones
contact affiliation	Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, L69 3BX, United Kingdom
contact email	jonesar@liverpool.ac.uk
lab head
Yasset Perez-Riverol
contact affiliation	EBI
contact email	yperez@ebi.ac.uk
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD068489

PRIDE project URI

• PRIDE
  1. PXD068489
     1. Label: PRIDE project
     2. Name: A landscape analysis of human SUMOylation: A comprehensive meta-analysis of publicly available datasets