PXD068427 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Molecular architecture of the tRNA ligase complex |
| Description | In human cells, a subset of tRNA-encoding genes contain introns. These are removed by a non-canonical splicing pathway in which the tRNA splicing endonuclease complex catalyzes intron excision and the resulting exons are subsequently ligated by the tRNA-ligase complex (tRNA-LC). The tRNA-LC is a hetero-pentameric protein assembly consisting of Ashwin, CGI-99, FAM98B, the DEAD-box helicase DDX1 and the catalytic subunit RTCB/HSPC117. We show that the paralogous proteins FAM98A and FAM98C underpin the assembly of compositionally distinct RTCB-containing complexes that lack Ashwin and may have distinct cellular functions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-08-04 |
| AnnouncementXML | Submission_2026-08-04_04:53:11.366.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Moritz Pfleiderer |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-16 14:03:54 | ID requested | |
| ⏵ 1 | 2026-08-04 04:53:11 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Human, tRNA, RNA, Protein complex |
Contact List
| Martin Jinek |
|---|
| contact affiliation | University of Zurich, Department of Biochemistry |
| contact email | jinek@bioc.uzh.ch |
| lab head | |
| Moritz Pfleiderer |
|---|
| contact affiliation | University of Zurich |
| contact email | mo.pfleiderer@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/08/PXD068427 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068427
- Label: PRIDE project
- Name: Molecular architecture of the tRNA ligase complex
