PXD068397 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Myocardial recovery with mechanical circulatory support is linked to alternative splicing and subcellular localization of CAMK2D |
| Description | Cardiac reverse remodeling occurs in a small subset of heart failure patients treated with guideline-directed therapies. This phenomenon, which is defined by reduced ventricular dilatation and improved systolic function, is most common in patients receiving left ventricular assist device (LVAD) therapy. Identifying therapeutic targets for initiating reverse remodeling is an area of great clinical interest, as these 40 patients experience improved outcomes and quality of life. Targets may be discovered among the unique molecular changes associated with partial myocardial functional recovery induced by LVAD; however, the mechanisms underlying this favorable response are incompletely understood. To identify molecular signatures of recovery, we studied paired pre- and post-LVAD myocardial samples from heart failure patients who received LVAD as a bridge-to-transplant (10 responders, 9 non-responders) and non-failing controls. We performed bulk RNA-sequencing, tandem-mass-tag (TMT) quantitative proteomics, and TMT quantitative phospho-proteomics with follow-up mechanistic and functional 50 investigations in primary rodent cardiomyocytes and human engineered heart tissues (EHTs). |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-12 |
| AnnouncementXML | Submission_2026-01-11_16:42:10.081.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD068397 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Christopher Ebmeier |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-15 18:02:25 | ID requested | |
| ⏵ 1 | 2026-01-11 16:42:11 | announced | |
Publication List
| 10.1161/circulationaha.125.075789; |
| 10.6019/PXD068397; |
| Martin TG, Hunt DR, Ebmeier CC, Dhand AP, Alamana C, Cleveland JC, Graw SL, Bruner S, Bristow MR, Mestroni L, Taylor MRG, Burdick JA, Ambardekar AV, Buttrick PM, Leinwand LA, Myocardial Recovery With Mechanical Circulatory Support Is Linked to Alternative Splicing and Subcellular Localization of CAMK2D. Circulation, ():(2026) [pubmed] |
Keyword List
| submitter keyword: LVAD proteomics |
Contact List
| Leslie Anne Leinwand |
|---|
| contact affiliation | Executive Science Officer, BioFrontiers InstituteDistinguished ProfessorProfessor, Howard Hughes Medical Institute MOLECULAR CELLULAR AND DEVELOPMENTAL BIOLOGY CU DENVER SCHOOL OF MEDICINE |
| contact email | Leslie.Leinwand@Colorado.edu |
| lab head | |
| Christopher Ebmeier |
|---|
| contact affiliation | University of Colorado Boulder |
| contact email | christopher.ebmeier@colorado.edu |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD068397 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068397
- Label: PRIDE project
- Name: Myocardial recovery with mechanical circulatory support is linked to alternative splicing and subcellular localization of CAMK2D
