PXD068367 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nitrated products formed on α-synuclein are preferentially incorporated into oligomers but excluded from fibrils: a mechanism for accumulation of neurotoxic species |
| Description | Post-translational modifications (PTMs) such as nitration of Tyr (Y) residues and di-tyrosine (DT) formation are known to impact the aggregation behavior of α-synuclein (α-syn), a protein closely linked to Parkinson’s disease. Using tetranitromethane (TNM) as a model nitrating agent, we systematically investigated the chemical modifications of α-syn and their consequences for aggregation. Mass spectrometry analysis revealed selective nitration of all four Tyr residues, with Y39 and Y125 being most susceptible. DT crosslinks were also observed, primarily involving Y39, but were disfavored at higher TNM concentrations, indicating competition between nitration and crosslinking pathways. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-06-19 |
| AnnouncementXML | Submission_2026-06-19_12:20:05.080.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Luke Gamon |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | nitrated L-tyrosine |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-15 02:30:58 | ID requested | |
| ⏵ 1 | 2026-06-19 12:20:05 | announced | |
Publication List
Keyword List
| submitter keyword: tetranitromethane |
| 3-nitrotyrosine |
| di-tyrosine |
| crosslinks |
| fibril formation |
| Parkinson’s |
| neurodegeneration |
Contact List
| Per Hägglund |
|---|
| contact affiliation | Department of Biomedical Sciences, University of Copenhagen, Denmark |
| contact email | hagglundperm@gmail.com |
| lab head | |
| Luke Gamon |
|---|
| contact affiliation | The University of Copenhagen |
| contact email | lgamon@sund.ku.dk |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD068367 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD068367
- Label: PRIDE project
- Name: Nitrated products formed on α-synuclein are preferentially incorporated into oligomers but excluded from fibrils: a mechanism for accumulation of neurotoxic species
