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PXD068365-1

PXD068365 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	DIA proteomics of human healthy and BRONJ mandible samples
Description	This dataset contains data-independent acquisition (DIA) LC–MS/MS proteomic profiles of human mandible tissues obtained from patients with bisphosphonate-related osteonecrosis of the jaw (BRONJ) and healthy controls. Frozen tissues were processed using phenol–methanol extraction, SP3-based cleanup, and tryptic digestion, followed by high-resolution LC–MS/MS in DIA mode. Protein identification and quantification were performed under a 1% FDR cutoff with intensity-based normalization. Comparative analysis revealed key alterations in BRONJ samples.
HostingRepository	iProX
AnnounceDate	2025-09-15
AnnouncementXML	Submission_2025-09-22_00:35:57.707.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yixin Shi
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-15 00:53:07	ID requested
⏵ 1	2025-09-22 00:35:58	announced

Publication List

Dataset with its publication pending

Keyword List

submitter keyword: BRONJ, proteomics, DIA, LC–MS/MS

Contact List

Junyu Chen
contact affiliation	West China Hospital of Stomatology, Sichuan University
contact email	junyuchen@scu.edu.cn
lab head
Yixin Shi
contact affiliation	West China Hospital of Stomatology, Sichuan University
contact email	shiyixinn@163.com
dataset submitter

Full Dataset Link List

iProX dataset URI