PXD068363-1

PXD068363 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Plasma Extracellular Vesicles from PSEN1-E280A and APOE3 Christchurch patients
Description	We isolated plasma EVs from MCI PSEN1E280A-APOE3 (n=10, mean age: 46, range 41-54), non-MCI PSEN1E280A-APOE3 (n=10, mean age: 34, range 22-48), and non-MCI PSEN1E280A-APOE3Ch (n=9, mean age: 35, range 16-51) participants, using differential centrifugation. EVs were characterized by nanoparticle tracking analysis, flow cytometry and LC-MS/MS analysis.
HostingRepository	PRIDE
AnnounceDate	2026-02-02
AnnouncementXML	Submission_2026-02-01_16:21:09.901.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lina Pineda
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Exploris 480

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-14 21:33:03	ID requested
⏵ 1	2026-02-01 16:21:10	announced

Publication List

Pineda-Lopez L, Aguillon D, Villar-Vesga J, Valderrama-Carmona P, Guerrero A, Upreti A, Arevalo-Alquichire S, Correa L, Mendez-Castellanos K, Casta, ñ, o D, Cardona-Gomez GP, Fernandez GJ, Kim LA, Arboleda-Velasquez JF, Posada-Duque R, Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease. Alzheimers Dement, 22(1):e71148(2026) [pubmed]
10.1002/alz.71148;

Pineda-Lopez L, Aguillon D, Villar-Vesga J, Valderrama-Carmona P, Guerrero A, Upreti A, Arevalo-Alquichire S, Correa L, Mendez-Castellanos K, Casta, ñ, o D, Cardona-Gomez GP, Fernandez GJ, Kim LA, Arboleda-Velasquez JF, Posada-Duque R, Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease. Alzheimers Dement, 22(1):e71148(2026) [pubmed]

10.1002/alz.71148;

Keyword List

submitter keyword: Mild Cognitive Impairment,Extracellular Vesicles, Plasma, Autosomal Dominant Alzheimer Disease, APOE3 Christchurch

submitter keyword: Mild Cognitive Impairment,Extracellular Vesicles, Plasma, Autosomal Dominant Alzheimer Disease, APOE3 Christchurch

Contact List

Rafael Posada-Duque
contact affiliation	Grupo de Neurociencias de Antioquia, SIU, Universidad de Antioquia, Colombia. Instituto de Biología, Facultad de Ciencias Exactas y Naturales, Universidad de Antioquia, Colombia.
contact email	rafael.posada@udea.edu.co
lab head
Lina Pineda
contact affiliation	Universidad de Antioquia
contact email	gisela.pineda@udea.edu.co
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD068363
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD068363

PRIDE project URI

Repository Record List

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