PXD068250-1

PXD068250 is an original dataset announced via ProteomeXchange.

Title	Fecal detection of calprotectin subunits links IBD activity with chronicity of intestinal inflammation.
Description	Quantification of the human S100A8/S100A9 tetrameric protein complex in stool, referred to as fecal calprotectin, is an extensively validated biomarker supporting the diagnosis and management of gastrointestinal diseases1,2. The quaternary protein structures (called configuration here) of S100A8 and S100A9 and their biological function in the human intestine is unknown. This study unravels a diagnostic value for fecal S100A9 detection in IBD and identifies pleiotropic inflammatory mechanisms of S100A8 and S100A9 homodimers in the intestine.
HostingRepository	PRIDE
AnnounceDate	2025-12-18
AnnouncementXML	Submission_2025-12-18_07:28:08.270.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Leopold Kremser
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-10 04:23:42	ID requested
⏵ 1	2025-12-18 07:28:09	announced

10.1053/j.gastro.2025.08.040;

Jukic A, Hilbe R, Zundel L, Willeit P, Faserl K, Plattner C, Zollner A, Meyer M, Siegmund K, Klepsch V, Marteau V, Vich Vila A, Schw, ä, rzler J, Vouk K, Kozsar A, Rieder D, Weichberger A, Sarg B, Grabherr F, Mayr L, Moser P, Nemati N, Scholl-B, ü, rgi S, Karall D, Vogel GF, Welz L, Aldrian D, Koch R, Pfister A, Ran Q, Kaser A, Blumberg RS, Tancevski I, Sommer F, Bacher P, Schreiber S, Rosenstiel P, Aden K, Baier G, Bakiri L, M, ü, ller T, Weiss G, Weersma RK, Trajanoski Z, Wagner EF, Tilg H, Adolph TE, Atreya I, Atreya R, Bacher P, Becker C, Bojarski C, Britzen-Laurent N, Bosch-Voskens C, Chang HD, Diefenbach A, G, ü, nther C, Hegazy AN, Hildner K, Klose CSN, Koop K, Krug S, K, ü, hl AA, Leppkes M, L, ó, pez-Posadas R, Ludwig LS, Neufert C, Neurath M, Patankar J, Pr, ü, ß M, Radbruch A, Romagnani C, Ronchi F, Sanders A, Scheffold A, Schulzke JD, Schumann M, Sch, ü, rmann S, Siegmund B, St, ü, rzl M, Triantafyllopoulou A, Waldner M, Weidinger C, Wirtz S, Zundler S, Fecal Detection of Calprotectin Subunits Links Inflammatory Bowel Disease Activity With Chronicity of Intestinal Inflammation. Gastroenterology, ():(2025) [pubmed]

submitter keyword: Calprotectin

S100A8

S100A9

Inflammatory bowel diseases

gut

Crohn's disease

Ulcerative colitis

adaptive immunity

inflammation

biomarker

NLRP1

inflammasome

Bettina Sarg
contact affiliation	Institute of Medical Biochemistry, Protein Core Facility, Medical University of Innsbruck, 6020 Innsbruck, Austria
contact email	bettina.sarg@i-med.ac.at
lab head
Leopold Kremser
contact affiliation	Medical University Innsbruck
contact email	leopold.kremser@i-med.ac.at
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/12/PXD068250

PRIDE project URI

• PRIDE
  1. PXD068250
     1. Label: PRIDE project
     2. Name: Fecal detection of calprotectin subunits links IBD activity with chronicity of intestinal inflammation.