PXD068217-2

PXD068217 is an original dataset announced via ProteomeXchange.

Title	Integrated Proteomic Profiling of Aqueous Humor Reveals CDC42/RHOA-Mediated Pathogenic Mechanisms in nAMD and PDR
Description	Neovascular AMD (nAMD) and proliferative diabetic retinopathy (PDR) are major blinding retinal diseases characterized by pathological angiogenesis. Using data-independent acquisition (DIA) proteomics, we analyzed aqueous humor from nAMD, PDR, and cataract control patients. Among 3186 identified proteins, 877 (nAMD) and 1017 (PDR) differentially expressed proteins (DEPs) were detected. Functional enrichment highlighted inflammatory and metabolic pathway dysregulation in both diseases. CDC42 and RHOA were consistently upregulated and implicated in cytoskeletal remodeling and angiogenesis. This study reveals shared molecular mechanisms in nAMD and PDR, proposing new targets for therapeutic intervention.
HostingRepository	iProX
AnnounceDate	2025-09-09
AnnouncementXML	Submission_2025-09-09_23:55:28.812.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lingjie Kong
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-09 01:24:57	ID requested
1	2025-09-09 01:25:18	announced
⏵ 2	2025-09-09 23:55:29	announced	2025-09-10: Update info.

Dataset with its publication pending

submitter keyword: neovascularization

nAMD

PDR

CDC42

RHOA

aqueous humor

biomarkers

inflammation

Chen Zhao
contact affiliation	Eye & ENT Hospital, Fudan University
contact email	dr_zhaochen@fudan.edu.cn
lab head
Lingjie Kong
contact affiliation	Eye & ENT Hospital, Fudan University
contact email	ljkong21@m.fudan.edu.cn
dataset submitter

iProX dataset URI