PXD068184-1

PXD068184 is an original dataset announced via ProteomeXchange.

Title	Tear biomarkers for early detection of LRRK2-associated Parkinson's disease
Description	Noninvasive biomarkers to distinguish idiopathic Parkinson’s disease (iPD) from monogenic forms and track progression remain elusive. We applied nanoLCMS/MS to characterise the tear proteome of 77 iPD patients, seven LRRK2 mutation carriers and 86 agematched controls. Of the 1,011 proteins identified, 465 differed significantly between iPD and controls (p < 0.05); imposing a ≥2fold change yielded six robust candidates. ENOB, MUC5AC, LMNA, COX2 and PSB1 were upregulated, whereas K895L was reduced in iPD. Comparison with the LRRK2 cohort revealed 14 discriminant proteins, notably VATB2, PARK7, RS8 and PROL1. VATB2 and RS8 showed positive correlations with motor disability, as assed by the Unified Parkinson’s Disease Rating Scale part II (UPDRS II); in contrast, VATB2 was inversely linked to tear volume, while PROL1 exhibited a direct association. These findings demonstrate that tearfluid proteomics differentiates iPD from LRRK2associated Parkinson’s disease, illuminate’s diseasespecific pathways and mirrors clinical heterogeneity through a simple ophthalmic sample. The resulting protein panels provide promising noninvasive biomarkers for early diagnosis, patient stratification and therapeutic monitoring, warranting validation in larger longitudinal cohorts.
HostingRepository	PRIDE
AnnounceDate	2026-06-19
AnnouncementXML	Submission_2026-06-19_10:07:56.142.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Mikel Azkargorta
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-08 07:35:09	ID requested
⏵ 1	2026-06-19 10:07:56	announced

Dataset with its publication pending

submitter keyword: LRRK2, tear proteomics,iPD, biomarker, label free

Felix Elortza
contact affiliation	Proteomics Platform cic bioGUNE Bizkaia Tech. Park Build. 800 Derio 48160 Spain
contact email	felortza@cicbiogune.es
lab head
Mikel Azkargorta
contact affiliation	Proteomics Platform CIC bioGUNE
contact email	mazkargorta@cicbiogune.es
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/06/PXD068184

PRIDE project URI

• PRIDE
  1. PXD068184
     1. Label: PRIDE project
     2. Name: Tear biomarkers for early detection of LRRK2-associated Parkinson's disease