PXD068084-1

PXD068084 is an original dataset announced via ProteomeXchange.

Title	Liver and kidney under opioid exposure, DIA data
Description	In the presented investigations we performed a quantitative proteomic analysis of rat liver and kidney tissues following exposure to morphine (10 mg/kg, once daily, for 10 days, intraperitoneally), compared to untreated controls. Although opioids are generally considered safe for both organs during short-term pain therapy, our data revealed significant alterations in protein expression that extend beyond classical metabolic enzymes. Notable, differences were observed in proteins related to pro- and anti-apoptotic signaling, oxidative stress response, transport mechanisms, transmembrane receptors, nucleic acid metabolism, and regulators of alternative splicing, among others. Liver tissue exhibited primarily adaptive changes, including upregulation of metabolic enzymes and subtle indications of oxidative stress based on marker profiles. In contrast, the kidneys displayed a broader spectrum of proteomic alterations, affecting a wider array of functional pathways, suggesting that this organ may be more susceptible to morphine-induced toxicity or that of its metabolites. Our results should be regarded as preliminary; however, they highlight a promising direction for identifying early-stage protein markers of toxicity using proteomic approaches. Monitoring such markers could prove valuable in multidrug therapies, particularly for patients with a history of hepatic or renal impairment, and may contribute to the development of safer therapeutic strategies.
HostingRepository	PRIDE
AnnounceDate	2026-01-26
AnnouncementXML	Submission_2026-01-25_17:45:12.368.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Piotr Suder
SpeciesList	scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116;
ModificationList	iodoacetamide derivatized residue
Instrument	Orbitrap Exploris 240

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-04 11:12:41	ID requested
⏵ 1	2026-01-25 17:45:13	announced

Hopcias M, Kret P, Kotlinska JH, Link-Lenczowski P, Bodzon-Kulakowska A, Suder P, Liver and Kidney Tissues Under Opioid Exposure: Rewriting and Old Story Through Proteomics and MALDI-MSI. J Proteome Res, 25(2):995-1004(2026) [pubmed]

10.1021/acs.jproteome.5c00764;

submitter keyword: liver, kidney, morphine influence, DIA data

Piotr Suder
contact affiliation	AGH University of Krakow, Mickiewicza 30 ave, 30-059 Krakow, Poland
contact email	psuder@agh.edu.pl
lab head
Piotr Suder
contact affiliation	AGH University of Krakow, Department of Materials Sciences and Ceramics, Mickiewicza 30, 30-059 Krakow, Poland
contact email	psuder@agh.edu.pl
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD068084
     1. Label: PRIDE project
     2. Name: Liver and kidney under opioid exposure, DIA data