PXD068025-1

PXD068025 is an original dataset announced via ProteomeXchange.

Title	Exosomal protein Profiling in Plasma of DOCA-Salt-Induced Hypertensive and Control Mice
Description	This study aimed to profile exosomal protein extracted from plasma of male and female mice treated with DOCA-salt (a model for hypertension) and corresponding baseline controls. The isolated exosomal proteins were sequenced using using LC-MS/MS (Orbitrap Exploris 480+FAIMS Pro). This approach may help identify molecular mechanisms related to sex-specific hypertension responses.This study aimed to profile exosomal protein extracted from plasma of male and female mice treated with DOCA-salt (a model for hypertension) and corresponding baseline controls. The isolated exosomal proteins were sequenced using using LC-MS/MS (Orbitrap Exploris 480+FAIMS Pro). This approach may help identify molecular mechanisms related to sex-specific hypertension responses.
HostingRepository	PRIDE
AnnounceDate	2026-02-09
AnnouncementXML	Submission_2026-02-08_16:19:55.582.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Vahideh Tarhriz
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-03 03:51:16	ID requested
⏵ 1	2026-02-08 16:19:56	announced

10.1016/j.ejphar.2025.178119;

Eivazi M, Hosseini K, Alipanahi S, Xia H, Restivo L, Patel A, Gozali M, Ebrahimi T, Scarborough A, Tarhriz V, Lazartigues E, Deep learning-driven proteomics analysis for gene annotation in the renin-angiotensin system. Eur J Pharmacol, 1006():178119(2025) [pubmed]

ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Human Proteome Project

submitter keyword: Hypertensive mice,Proteomics, Extracellular vesicles

Vahideh Tarhriz
contact affiliation	Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, 70112, USA
contact email	vtarhr@lsuhsc.edu
lab head
Vahideh Tarhriz
contact affiliation	LSU Health Science Center, New Orleans, Louisiana
contact email	vtarhr@lsuhsc.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD068025

PRIDE project URI

• PRIDE
  1. PXD068025
     1. Label: PRIDE project
     2. Name: Exosomal protein Profiling in Plasma of DOCA-Salt-Induced Hypertensive and Control Mice