PXD068006-1

PXD068006 is an original dataset announced via ProteomeXchange.

Title	Plastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in Hidradenitis Suppurativa skin disease
Description	Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition often characterized by nodules, cysts, and tunneling sinus tracts. Incidence of HS varies by study, anywhere from 0.1% to 2% of the general population, and is increasing over time. Despite its common occurrence, the only FDA approved therapies for HS are antibodies against TNFα (Adalimumab) and IL-17A (Secukinumab). Response rates can be as low as 40%, underscoring the necessity of further investigation and new therapies. Female sex, obesity, and metabolic syndrome have the strongest associations with HS. In addition to metabolic syndrome, there are other hormonal associations with HS—the average age of onset is between 21 and 24, and prepubertal HS is rare. Additionally, 78% of adult females with HS report flares associated with their menstrual cycle. Another association in HS is ultra-processed foods (UPFs) consumption; Non-Hispanic Black populations consume the most UPFs and have the highest HS incidence, while Hispanic populations consume the least UPFs and have the lowest HS incidence, despite similar rates of obesity. Overall, the association of HS with UPF consumption and endocrine disorders suggest novel avenues of investigation.
HostingRepository	PRIDE
AnnounceDate	2025-10-20
AnnouncementXML	Submission_2025-10-20_15:09:53.211.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Temple Andrews Temple Andrews
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Bruker Daltonics solarix series

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-02 13:40:56	ID requested
⏵ 1	2025-10-20 15:09:53	announced

Dataset with its publication pending

submitter keyword: Nicastrin, Skin, Hidradenitis Suppurativa, Imaging

Maureen Kane
contact affiliation	University of Maryland School of Pharmacy
contact email	mkane@rx.umaryland.edu
lab head
Temple Andrews Temple Andrews
contact affiliation	University of Maryland School of Pharmacy
contact email	wandrew3@alumni.nd.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD068006

PRIDE project URI

• PRIDE
  1. PXD068006
     1. Label: PRIDE project
     2. Name: Plastic associated endocrine disruptors reduce Nicastrin protein and potentiate inflammation in Hidradenitis Suppurativa skin disease