PXD067999 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Liver and kidney under opioid exposure, DDA data |
| Description | In the presented investigations we performed a quantitative proteomic analysis of rat liver and kidney tissues following exposure to morphine (10 mg/kg, once daily, for 10 days, intraperitoneally), compared to untreated controls. Although opioids are generally considered safe for both organs during short-term pain therapy, our data revealed significant alterations in protein expression that extend beyond classical metabolic enzymes. Notable, differences were observed in proteins related to pro- and anti-apoptotic signaling, oxidative stress response, transport mechanisms, transmembrane receptors, nucleic acid metabolism, and regulators of alternative splicing, among others. Liver tissue exhibited primarily adaptive changes, including upregulation of metabolic enzymes and subtle indications of oxidative stress based on marker profiles. In contrast, the kidneys displayed a broader spectrum of proteomic alterations, affecting a wider array of functional pathways, suggesting that this organ may be more susceptible to morphine-induced toxicity or that of its metabolites. Here DDA data from both experiments, on liver and kidneys, are presented. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-26 |
| AnnouncementXML | Submission_2026-01-25_17:40:38.277.xml |
| DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD067999 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Piotr Suder |
| SpeciesList | scientific name: Rattus norvegicus (Rat); NCBI TaxID: NEWT:10116; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 240 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-02 07:20:51 | ID requested | |
| ⏵ 1 | 2026-01-25 17:40:40 | announced | |
Publication List
| 10.6019/PXD067999; |
| Hopcias M, Kret P, Kotlinska JH, Link-Lenczowski P, Bodzon-Kulakowska A, Suder P, Liver and Kidney Tissues Under Opioid Exposure: Rewriting and Old Story Through Proteomics and MALDI-MSI. J Proteome Res, 25(2):995-1004(2026) [pubmed] |
| 10.1021/acs.jproteome.5c00764; |
Keyword List
| submitter keyword: liver kidney morphine DDA |
Contact List
| Piotr Suder |
|---|
| contact affiliation | AGH University of Krakow, Mickiewicza 30 ave., 30-059 krakow, Poland |
| contact email | psuder@agh.edu.pl |
| lab head | |
| Piotr Suder |
|---|
| contact affiliation | AGH University of Krakow, Department of Materials Sciences and Ceramics, Mickiewicza 30, 30-059 Krakow, Poland |
| contact email | psuder@agh.edu.pl |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067999
- Label: PRIDE project
- Name: Liver and kidney under opioid exposure, DDA data
