PXD067981-1

PXD067981 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Targeting SKAP2-modulated cytoskeleton remodeling restores sperm motility
Description	Our work recognized heterogeneous nuclear ribonucleoprotein R (hnRNPR) is a master regulator of m6A-dependent pre-mRNA splicing. Genetic mutation in HNRNPR leads to asthenoteratozoospermia in both humans and mice, culminating in complete sterility. Mechanistically, genetic ablation of Hnrnpr manifests widespread transcriptomic, proteomics, and m6A-modified splicing dysregulation, disrupting these genes essential for acrosome formation and flagellum development.
HostingRepository	PRIDE
AnnounceDate	2025-09-13
AnnouncementXML	Submission_2025-09-13_00:18:20.842.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Jiaming Zhou
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	No PTMs are included in the dataset
Instrument	LTQ

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-02 04:46:07	ID requested
⏵ 1	2025-09-13 00:18:21	announced

Publication List

Dataset with its publication pending

Dataset with its publication pending

Keyword List

submitter keyword: LC-MS

submitter keyword: LC-MS

Contact List

Shiming Gan
contact affiliation	Zhejiang University
contact email	shiminggan@zju.edu.cn
lab head
Jiaming Zhou
contact affiliation	Institute of Reproduction and Development, Obstetrics and Gynecology Hospital of Fudan University
contact email	24211250021@m.fudan.edu.cn
dataset submitter

Full Dataset Link List

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD067981
PRIDE project URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD067981

PRIDE project URI

Repository Record List

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