PXD067971-1

PXD067971 is an original dataset announced via ProteomeXchange.

Title	Epigenetic resetting in the Parkinson's disease entail histone modification remodeling.
Description	Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons (DN) in the substantia nigra and disrupted cellular maintenance. Here, we demonstrate that NDST3-mediated epigenetic reprogramming halts neuronal degeneration and restores motor function in a PD animal model. Following NDST3 administration, DN and associated circuits in the substantia nigra and striatum show marked revitalization, accompanied by significant alleviation of PD-like motor deficits. Integrative single-cell and spatial RNA sequencing with ChIP sequencing reveal that NDST3-driven reactivation of pathways linked to neuronal survival, synaptic integrity, steering compromised cells toward a resilient phenotype. By recalibrating the epigenetic landscape, NDST3 fosters cellular maintenance and functional recovery within key motor circuits. These findings highlight NDST3’s therapeutic potential as epigenetic modulator in PD. Our findings provide insights into the mechanisms underlying neuronal revitalization and underscore the promise of NDST3 as a novel agent for restoring brain function in neurodegenerative conditions.
HostingRepository	PRIDE
AnnounceDate	2026-03-16
AnnouncementXML	Submission_2026-03-16_05:12:07.850.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yongwoo Na
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Eclipse

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-02 01:44:47	ID requested
⏵ 1	2026-03-16 05:12:08	announced

10.1002/advs.202507323;

Chang Y, Na Y, Im H, Yang G, Yang S, Shim HS, Kim C, Kim G, Park HJ, Kim HY, Lee SE, Lee W, Ha Y, Park S, Kim J, Cho WY, Sun W, Kim JS, Yoo J, NDST3-Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease. Adv Sci (Weinh), 13(14):e07323(2026) [pubmed]

submitter keyword: Human, TMT, Parkinson's, organoid, LC-MS/MS

Jong-Seo Kim
contact affiliation	Center for RNA Research, Institute for Basic Science, Seoul 08826, S. Korea School of Biological Sciences, Seoul National University, Seoul 08826, S. Korea
contact email	jongseokim@snu.ac.kr
lab head
Yongwoo Na
contact affiliation	Seoul National University
contact email	nyw1412@snu.ac.kr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/03/PXD067971

PRIDE project URI

• PRIDE
  1. PXD067971
     1. Label: PRIDE project
     2. Name: Epigenetic resetting in the Parkinson's disease entail histone modification remodeling.