PXD067951 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comprehensive and Unbiased Plasma Proteomics with Proteograph |
| Description | Mild Cognitive Impairment (MCI) is a precursor to Alzheimer's disease (AD), necessitating early identification through reliable markers. We employed ProteographTM, an automated platform utilizing nanoparticles coupled with a liquid chromatography-tandem mass spectrometry (LC-MS/MS) workflow, enabling comprehensive, unbiased detection of low-abundance proteins (LAPs) in plasma. We analyzed the plasma proteome from 42 MCI patients and 13 controls. A total of 35 differentially expressed proteins (DEPs) were identified, with significant correlations to Mini-Mental State Examination (MMSE) scores. Composite panels of candidate proteins exhibited potential for distinguishing MCI and its subtypes, providing insight into underlying pathophysiological mechanisms. Our findings identify novel blood protein candidates with potential to enhance early MCI diagnosis and provide insight into the progression of AD. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-06_17:56:39.508.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Seung Joon Lee |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-01 06:24:38 | ID requested | |
| ⏵ 1 | 2026-09-06 17:56:40 | announced | |
Publication List
| Kim JH, Kwon OK, Jang WC, Jeong HK, Lee KJ, Oh C, Lee KM, Choi KH, Han X, Lee SJ, Lee SB, Nanoparticle-enriched mass spectrometry enables comprehensive plasma proteomics and reveals novel candidates for mild cognitive impairment. Sci Rep, 16(1):(2026) [pubmed] |
| 10.1038/s41598-026-47088-3; |
Keyword List
| submitter keyword: Proteograph, Mild cognitive impairment,Human Plasma |
Contact List
| Seok Bum Lee |
|---|
| contact affiliation | Department of Psychiatry, Dankook University Hospital |
| contact email | bumlee@dankook.ac.kr |
| lab head | |
| Seung Joon Lee |
|---|
| contact affiliation | Soulbrain Holdings Co., Ltd. |
| contact email | fovero1007@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD067951 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067951
- Label: PRIDE project
- Name: Comprehensive and Unbiased Plasma Proteomics with Proteograph
