PXD067933 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | NAT10-mediated ac4C-modification exacerbates ferroptosis by stabilizing HMOX1 in Deep vein thrombosis |
| Description | In our study, we aimed to identify the pathways and genes closely related to DVT. Through proteomic analysis, we found that the ferroptosis signaling pathway showed differential expression, and we also discovered that NAT10 (a key acetyltransferase modified by ac4C) was significantly overexpressed in DVT mice. Based on this discovery, we further investigated the downstream genes regulated by NAT10. We found that NAT10 enhances the stability of HMOX1 through ac4C modification, which results in iron overload and lipid peroxides, thereby forming a positive feedback loop that exacerbates DVT. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-26 |
| AnnouncementXML | Submission_2026-01-25_16:37:18.568.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yunhong Zhang |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-09-01 01:39:15 | ID requested | |
| ⏵ 1 | 2026-01-25 16:37:19 | announced | |
Publication List
| 10.1161/atvbaha.125.323986; |
| Zhang Y, Zhang Z, Liu X, Chu C, Yu X, Han Q, Li W, Zhang T, Zu H, Fan N, Wei R, Shi F, Li F, Xu F, Wang B, Li X, NAT10-Mediated ac4C-Modification Exacerbates Ferroptosis by Stabilizing HMOX1 in Deep Vein Thrombosis. Arterioscler Thromb Vasc Biol, 46(2):e323986(2026) [pubmed] |
Keyword List
| submitter keyword: Deep venous thrombosis |
| NAT10 |
| ac4C |
| HMOX1 |
| Ferroptosis |
Contact List
| Xia Li |
|---|
| contact affiliation | Shandong University of Traditional Chinese Medicine |
| contact email | 60230033@sdutcm.edu.cn |
| lab head | |
| Yunhong Zhang |
|---|
| contact affiliation | Shandong University of Traditional Chinese Medicine |
| contact email | 972384131@qq.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD067933 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067933
- Label: PRIDE project
- Name: NAT10-mediated ac4C-modification exacerbates ferroptosis by stabilizing HMOX1 in Deep vein thrombosis
