PXD067927-1

PXD067927 is an original dataset announced via ProteomeXchange.

Title	BEAS-2B Arsenic/Nickel treatmen iTRAQ proteomic analysis
Description	Lung cancer accounts for approximately 2.2 million new cases worldwide, making it the second most prevalent cancer. Annually, it results in 1.8 million fatalities, rendering it the cancer with the highest mortality rate. A significant proportion of lung cancer patients have a history of environmental and occupational exposures. Both the International Agency for Research on Cancer (IARC) and the U.S. Environmental Protection Agency (EPA) identify arsenic and nickel as significant environmental carcinogens. However, the specific mechanisms by which these substances induce lung cancer remain unclear. Therefore, we conducted acute exposure experiments on human bronchial epithelial cells using varying concentrations of arsenic and nickel compounds, followed by proteomic analysis to identify the altered proteins. This study aims to elucidate the potential carcinogenic mechanisms associated with arsenic and nickel compounds.
HostingRepository	iProX
AnnounceDate	2025-09-01
AnnouncementXML	Submission_2025-11-09_23:31:39.475.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lingling Zhao
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	iTRAQ8plex reporter+balance reagent acylated residue
Instrument	TripleTOF 5600

Revision	Datetime	Status	ChangeLog Entry
0	2025-09-01 01:26:17	ID requested
⏵ 1	2025-11-09 23:31:40	announced

Dataset with its publication pending

submitter keyword: BEAS-2B, Arsenci, Nickel, lung cancer, acute exposure

Haishan Huang
contact affiliation	Wenzhou Medical University
contact email	haishan_333@163.com
lab head
Lingling Zhao
contact affiliation	Wenzhou Medical University
contact email	zhaolingling@wmu.edu.cn
dataset submitter

iProX dataset URI