PXD067859-1

PXD067859 is an original dataset announced via ProteomeXchange.

Title	abdominal aortic aneurysm (AAA) proteomics
Description	An abdominal aortic aneurysm (AAA) is a pathological dilatation of the aortic wall and it is a life-threatening disease due to the risk of rupture. Currently, surgical intervention remains the only definitive treatment recommended for large or rapidly expanding aneurysms. No pharmacological therapy is currently available to prevent AAA progression, as no drug has been proven effective. Diabetes is a major risk factor for cardiovascular disease in general. However, many studies over the last decade show that type 2 diabetes patients have a lower incidence of AAA and a slower aneurysm growth rate, which has been correlated with metformin use. We performed a proteomics analysis on resected aortic tissue from controls, non-diabetic (ND) and diabetic (D) AAA patients.
HostingRepository	PRIDE
AnnounceDate	2025-09-29
AnnouncementXML	Submission_2025-09-29_00:58:40.804.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Thang Pham
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
Instrument	timsTOF HT

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-28 16:54:27	ID requested
⏵ 1	2025-09-29 00:58:41	announced

10.3390/medsci13030184;

van Merrienboer TAR, Rombouts KB, van Wijk ACWA, Knol JC, Pham TV, Piersma SR, Jimenez CR, Balm R, Yeung KK, de Waard V, Proteome Differences in Smooth Muscle Cells from Diabetic and Non-Diabetic Abdominal Aortic Aneurysm Patients Reveal Metformin-Induced Mechanisms. Med Sci (Basel), 13(3):(2025) [pubmed]

submitter keyword: DIA-MS, human tissue,abdominal aortic aneurysm

Connie Jimenez
contact affiliation	OncoProteomics Laboratory, Dept of Medical Oncology, Amsterdam University Medical Centers, Amsterdam, The Netherlands
contact email	c.jimenez@amsterdamumc.nl
lab head
Thang Pham
contact affiliation	Amsterdam UMC
contact email	t.pham@amsterdamumc.nl
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD067859

PRIDE project URI

• PRIDE
  1. PXD067859
     1. Label: PRIDE project
     2. Name: abdominal aortic aneurysm (AAA) proteomics