PXD067844 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Mesothelin Promotes Acute Myeloid Leukemia Cell Proliferation, Adhesion, and Chemoresistance via Novel Binding Partner Lyn |
| Description | MSLN has only been implicated to have one binding partner, MUC16/CA125. In an effort to identifying novel binding partners of MSLN, an IP-MS experiment was conducted using immunoprecipitations of MSLN in whole cell lysate of NOMO-1 and MSLN KO cells. We identified Src-family kinase member Lyn, and guanine nucleotide-binding protein G(i), alpha subunit proteins, GNAI1, GNAI2, and GNAI3 as a novel binding partners of MSLN in AML. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-04-27 |
| AnnouncementXML | Submission_2026-04-26_16:55:01.443.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD067844 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Joshua Faust |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | acetylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-28 08:57:52 | ID requested | |
| ⏵ 1 | 2026-04-26 16:55:02 | announced | |
Publication List
| 10.6019/PXD067844; |
| 10.1016/j.jbc.2026.111390; |
| Faust JR, Hamill D, Kolb EA, Stevens AM, Gopalakrishnapillai A, Barwe SP, Mesothelin promotes acute myeloid leukemia progression through LYN-dependent signaling. J Biol Chem, 302(5):111390(2026) [pubmed] |
Keyword List
| submitter keyword: leukemia, IP-MS,MSLN, AML |
Contact List
| Sonali P. Barwe, PhD |
|---|
| contact affiliation | Nemours Children’s Hospital, DE |
| contact email | sonali.barwe@nemours.org |
| lab head | |
| Joshua Faust |
|---|
| contact affiliation | Nemours Children's Hospital |
| contact email | josh.faust@nemours.org |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067844 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067844
- Label: PRIDE project
- Name: Mesothelin Promotes Acute Myeloid Leukemia Cell Proliferation, Adhesion, and Chemoresistance via Novel Binding Partner Lyn
