PXD067836 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Engineering Linear Cap-independent mRNA Vaccines with Intrinsic 1 Adjuvanticity for Potent Cancer Immunotherapy |
| Description | We present 25 a streamlined linear cap-independent RNA (LciRNA) cancer vaccine platform that achieves stable 26 expression in vivo without 5’ capping or ribonucleotide modification, and innately stimulates 27 immune responses to enhance antitumor immunity. By fusing a UPA protective sequence, composed 28 of a viral exoribonuclease-resistant RNA (xrRNA) and a poly(A) binding protein (PABP) motif, 29 with an optimized Enterovirus A internal ribosome entry site, LciRNA resists 5’ exonuclease decay 30 and drives superior in vivo expression. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-26 |
| AnnouncementXML | Submission_2026-01-25_19:07:01.879.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shenglin Huang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | autoflex |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-28 07:09:59 | ID requested | |
| ⏵ 1 | 2026-01-25 19:07:02 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: LciRNA， UPA |
Contact List
| Shenglin Huang |
|---|
| contact affiliation | Fudan Uninversity, Shanghai Cancer Center |
| contact email | slhuang@fudan.edu.cn |
| lab head | |
| Shenglin Huang |
|---|
| contact affiliation | Fudan University Shanghai Cancer Center |
| contact email | slhuang@fudan.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD067836 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067836
- Label: PRIDE project
- Name: Engineering Linear Cap-independent mRNA Vaccines with Intrinsic 1 Adjuvanticity for Potent Cancer Immunotherapy
