PXD067792 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Dynamic cytoplasmic fluidity at the mesoscale during morphogenesis in a human fungal pathogen |
| Description | The molecular crowding of the cytoplasm impacts a range of cellular processes. Using a fluorescent microrheological probe (GEMs), we observed a striking increase in mesoscale diffusion during the yeast to filamentous growth transition in the human fungal pathogen Candida albicans. This increase in mesoscale diffusion is due to a decrease in ribosome concentration that results in part from an inhibition of ribosome biogenesis, combined with an increase in cytoplasmic volume, leading to a dilution of a major cytoplasmic crowder at the mesoscale. Moreover, our results suggest that inhibition of ribosome biogenesis is a trigger for C. albicans morphogenesis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-11-13 |
| AnnouncementXML | Submission_2025-11-13_06:22:48.734.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Ludwig Sinn |
| SpeciesList | scientific name: Candida albicans (Yeast); NCBI TaxID: NEWT:5476; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | ZenoTOF 7600 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-27 03:47:15 | ID requested | |
| ⏵ 1 | 2025-11-13 06:22:49 | announced | |
Publication List
Keyword List
Contact List
| Markus Ralser |
|---|
| contact affiliation | Charité - Universitätsmedizin Berlin Research group Biochemistry and Systems Biology of the Metabolism Institute of Biochemistry Germany |
| contact email | markus.ralser@charite.de |
| lab head | |
| Ludwig Sinn |
|---|
| contact affiliation | Charité – Universitätsmedizin Berlin |
| contact email | ludsinn@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD067792 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067792
- Label: PRIDE project
- Name: Dynamic cytoplasmic fluidity at the mesoscale during morphogenesis in a human fungal pathogen
