PXD067677-1
PXD067677 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Comprehensive Human Red Blood Cell Proteome Analyses |
| Description | Red blood cells (RBCs) are essential in carrying oxygen to human for maintenance of life and involved in many clinical disorders. Many proteomics studies have been done on RBCs, but the depths are insufficient, limiting better understanding of protein profiles of RBCs and molecular mechanisms of their diseases. With major advances that have been made in the mass spectrometry-based proteomics filed, here we have well prepared RBCs into the membrane and cytoplasmic fractions and performed in-depth proteomics analyses respectively. The two deep proteomics analyses involved extensive basic pH RPLC fractionation (~100 fractions collected) and individual analysis without concatenation, yielding identification of 4777 proteins in the RBC membrane fraction, 2350 proteins in the cytoplasmic fraction, and 5264 proteins in total, presenting almost the largest scale in the human RBC proteome analysis field. This comprehensive RBC proteome study will provide useful datasets for better understanding human RBCs and the molecular mechanisms of their involved diseases. |
| HostingRepository | iProX |
| AnnounceDate | 2025-08-24 |
| AnnouncementXML | Submission_2025-08-24_23:37:13.270.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Bing Bai |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-08-24 23:36:49 | ID requested | |
| ⏵ 1 | 2025-08-24 23:37:13 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Red blood cell, membrane extract, cytoplasmic extract, LC-MS/MS, proteomics |
Contact List
| Bing Bai | |
|---|---|
| contact affiliation | Nanjing University |
| contact email | bing.bai@nju.edu.cn |
| lab head | |
| Bing Bai | |
| contact affiliation | Nanjing University |
| contact email | bing.bai@nju.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
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