PXD067645-1

PXD067645 is an original dataset announced via ProteomeXchange.

Title	Effects of apolipoprotein E on the seeding properties of amyloid-β peptide
Description	The apolipoprotein E (APOE) e4 allele is known to be the strongest genetic risk factor for the development of Alzheimer’s disease. Previous studies have demonstrated that apoE, encoded by the APOE gene, affects Aβ deposition in a dose-, species-, and isoform-dependent manner; however, the detailed molecular mechanisms remain unclear. We recently demonstrated that soluble Aβ species (> 150 kDa) in the brains of Alzheimer’s disease patients act as key aggregation seeds in β-amyloidosis. In this study, using mass spectrometry analysis, we identified apoE as an interactor of these Aβ species.
HostingRepository	jPOST
AnnounceDate	2026-08-24
AnnouncementXML	Submission_2026-08-23_08:00:06.372.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Hirokazu Uchigami
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	S-carboxamidomethyl-L-cysteine; L-methionine sulfoxide
Instrument	instrument

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-23 08:58:47	ID requested
⏵ 1	2026-08-23 08:00:06	announced

Dataset with its publication pending

submitter keyword: apoE, proteomics, Aβ seed

Tadafumi Hashimoto
lab head
Hirokazu Uchigami
contact affiliation	National Institute of Neuroscience, National Center of Neurology and Psychiatry
dataset submitter

jPOST dataset URI

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