⮝ Full datasets listing
PXD067623-1
PXD067623 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Impact of intermittent lead exposure on hominid brain evolution |
| Description | Lead Exposure and Human Brain Evolution: A 2-Million-Year Perspective This study reveals that lead exposure was pervasive throughout human evolution, not just a modern phenomenon. Researchers analyzed 51 fossil teeth from multiple hominid species spanning 2+ million years across three continents, finding lead exposure evidence in 73% of specimens using advanced laser ablation mass spectrometry. The team then used human brain organoids carrying either modern or archaic (Neanderthal-like) variants of the NOVA1 gene to test lead's neurological impacts. They discovered that the archaic variant showed greater vulnerability to lead-induced disruption of FOXP2 expression—a gene crucial for speech and language development. This suggests environmental lead exposure may have created evolutionary pressure favoring the modern human NOVA1 variant, potentially giving our species advantages in communication and social cohesion. The research challenges established paradigms about both environmental toxin history and human evolution, proposing that gene-environment interactions with neurotoxins helped shape our species' cognitive development over millions of years. |
| HostingRepository | PRIDE |
| AnnounceDate | 2025-10-27 |
| AnnouncementXML | Submission_2025-10-26_20:41:33.988.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Paulo Carvalho |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-08-22 13:19:15 | ID requested | |
| ⏵ 1 | 2025-10-26 20:41:35 | announced |
Publication List
| Joannes-Boyau R, de Souza JS, Arora M, Austin C, Westaway K, Moffat I, Wang W, Liao W, Zhang Y, Adams JW, Fiorenza L, D, é, rognat F, Moncel MH, Schwartz GT, Bailey M, Dos Santos FF, Guardia GDA, Mercuri RLV, Galante PAF, Martins AMA, Tsu BL, Barnes CA, Yates J, Petroski LP, Sanchez-Sanchez SM, Oviedo J, Herai RH, Lemos B, Tonge M, Muotri AR, Impact of intermittent lead exposure on hominid brain evolution. Sci Adv, 11(42):eadr1524(2025) [pubmed] |
| 10.1126/sciadv.adr1524; |
Keyword List
| submitter keyword: Lead exposure |
| Hominid brain evolution |
| NOVA1–FOXP2 axis |
Contact List
| Aline Martins | |
|---|---|
| contact affiliation | ISSCOR / UCSD |
| contact email | ammartins@health.ucsd.edu |
| lab head | |
| Paulo Carvalho | |
| contact affiliation | Fiocruz |
| contact email | paulo@pcarvalho.com |
| dataset submitter | |
Full Dataset Link List
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/10/PXD067623 |
| PRIDE project URI |
Repository Record List
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