PXD067556-1

PXD067556 is an original dataset announced via ProteomeXchange.

Title	Trigger Factor in Burkholderia pseudomallei is essential for key virulence determinants including host cell internalisation, cytotoxicity, motility and stress resistance.
Description	Melioidosis is a potentially fatal infection caused by Burkholderia pseudomallei, a bacterium that is intrinsically resistant to many commonly used antibiotics. Therefore, the identification of new drug targets is essential for the development of new and effective therapies. This study demonstrates that the Trigger Factor protein, encoded by BPSL1402, is important for the establishment of B. pseudomallei infection and is involved in multiple facets of virulence including motility, cell cytotoxicity and resistance to stress. With reports of B. pseudomallei isolated from new regions and resistance to current treatment options, the significance of this research is the identification of a novel B. pseudomallei virulence factor that can be potentially exploited for the development of new therapeutics to treat this deadly infection.
HostingRepository	PRIDE
AnnounceDate	2026-04-07
AnnouncementXML	Submission_2026-04-07_02:11:40.870.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nichollas Scott
SpeciesList	scientific name: Burkholderia pseudomallei (strain K96243); NCBI TaxID: NEWT:272560;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-21 05:25:47	ID requested
⏵ 1	2026-04-07 02:11:41	announced

Dataset with its publication pending

submitter keyword: LFQ,Burkholderia pseudomallei

Dr Mitali Sarkar-Tyson
contact affiliation	Marshall Centre for Infectious Diseases Research and Training, School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia
contact email	mitali.sarkar-tyson@uwa.edu.au
lab head
Nichollas Scott
contact affiliation	University of Melbourne
contact email	nichollas.scott@unimelb.edu.au
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067556

PRIDE project URI

• PRIDE
  1. PXD067556
     1. Label: PRIDE project
     2. Name: Trigger Factor in Burkholderia pseudomallei is essential for key virulence determinants including host cell internalisation, cytotoxicity, motility and stress resistance.