PXD067494-1

PXD067494 is an original dataset announced via ProteomeXchange.

Title	Magnesium deficiency accelerates gut aging and increases susceptibility to colitis
Description	Metabolic imbalance drives organ aging and diseases, but the underlying mechanisms remain elusive. Here, we identify magnesium (Mg) deficiency as is a risk factor of gut health with age across species (human, primate, murine). Although Mg restriction had minimal effects in young mice, it exacerbated intestinal aging phenotypes in older animals and aggravated colitis severity. Integrated multi-omics analysis revealed that Mg deficiency remodels the phosphoproteome and N-glycoproteome and disrupts proteostasis, leading to destabilization of adhesion complexes, a hallmark of gut aging and inflammation. UK Biobank analysis (n=182,213) demonstrated a robust inverse correlation between dietary Mg intake and gut disorder incidence. Notably, a daily Mg intake of 334.7–420 mg/day conferred significant protection against Crohn’s disease, ulcerative colitis, irritable bowel syndrome, and diverticular disease. Our findings establish Mg homeostasis as a fundamental regulator of gut health and propose dietary Mg supplementation as a potential strategy to mitigate age-related gut dysfunction.
HostingRepository	iProX
AnnounceDate	2025-08-18
AnnouncementXML	Submission_2025-08-18_21:04:59.676.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Rou Zhang
SpeciesList	scientific name: Macaca fascicularis fascicularis; NCBI TaxID: 1215360; scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	N-glycosylated residue; phosphorylated residue
Instrument	Q Exactive HF; Q Exactive HF-X

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-18 21:04:34	ID requested
⏵ 1	2025-08-18 21:05:00	announced

Dataset with its publication pending

submitter keyword: magnesium ,gut aging, inflammation

Lunzhi Dai
contact affiliation	Sichuan University
contact email	lunzhi.dai@scu.edu.cn
lab head
Rou Zhang
contact affiliation	Sichuan University
contact email	zhangrou0518@163.com
dataset submitter

iProX dataset URI