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PXD067487-1

PXD067487 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic analysis of FABP5 oxidative modifications in LPS-stimulated BMDMs under antioxidant treatment
DescriptionThis study aims to investigate the oxidative modifications of FABP5 in macrophages during inflammatory stimulation and how these changes are affected by antioxidant treatment. Bone marrow-derived macrophages (BMDMs) were pretreated with 5 mM N-acetylcysteine (NAC) or 250 μM Tempol for 2 hours, followed by stimulation with 500 ng/mL LPS for 30 minutes. Cytoplasmic proteins were extracted, FABP5 was immunoprecipitated, and the immunoprecipitated proteins were analyzed by LC-MS/MS to identify oxidative modifications of FABP5 and determine the regulatory effects of antioxidants under inflammatory conditions.
HostingRepositoryiProX
AnnounceDate2025-08-19
AnnouncementXMLSubmission_2025-08-18_19:12:36.999.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterRong Wu
SpeciesList scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02025-08-18 19:12:14ID requested
⏵ 12025-08-18 19:12:37announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: FABP5, oxidation, BMDMs
Contact List
Shenhai Gong
contact affiliationSouthern Medical University
contact emailgsh0526@smu.edu.cn
lab head
Rong Wu
contact affiliationSouthern Medical University
contact emailwrong1995@163.com
dataset submitter
Full Dataset Link List
iProX dataset URI

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