PXD067472 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Targeting Ubiquitin Signaling vulnerabilities in KEAP1-Inactivated Lung Cancer |
| Description | Lung cancer cells rely on protein homeostasis regulators, especially within the ubiquitin-proteasome system (UPS), to sustain malignancy. Genetic alterations in UPS components, such as E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs), are common and create context-dependent therapeutic dependencies. We have investigated how these changes drive tumor formation, we conducted CRISPR screens on metabolically stressed murine lung cancer models and identified specific cancer vulnerabilities, including KEAP1. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-02-04 |
| AnnouncementXML | Submission_2026-02-04_02:09:24.249.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Rubina Kazi |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-18 08:33:27 | ID requested | |
| ⏵ 1 | 2026-02-04 02:09:24 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Mouse,KP,Lung,KPL,KPP |
Contact List
| Prof. Ivan Dikic |
|---|
| contact affiliation | Professor Institute of Biochemistry II Goethe University Medical Faculty University Hospital Building 75 Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany |
| contact email | dikic@biochem2.uni-frankfurt.de |
| lab head | |
| Rubina Kazi |
|---|
| contact affiliation | Postdoc |
| contact email | kazi@med.uni-frankfurt.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/02/PXD067472 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067472
- Label: PRIDE project
- Name: Targeting Ubiquitin Signaling vulnerabilities in KEAP1-Inactivated Lung Cancer
