⮝ Full datasets listing
PXD067444-1
PXD067444 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Cathepsin K inhibitor and hUMSC-EVs synergistically promote diabetic wound healing by suppressing ferroptosis |
| Description | Refractory chronic diabetic wounds severely threaten patient survival, yet current treatments fail to adequately promote healing or prevent amputations. Cathepsin K (CTSK), a collagen-degrading protease upregulated in early diabetic wounds, presents a potential therapeutic target, while human umbilical cord mesenchymal stem cell-derived extracellular vesicles (hUMSC-EVs) show promise in regeneration but are limited by high costs and instability. This study hypothesizes that combining a stable, cost-effective CTSK inhibitor with hUMSC-EVs could enhance therapeutic efficacy and overcome these challenges. The hypothesis was tested using diabetic wound models in db/db mice and high glucose-exposed human dermal fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs). The combination of CTSK inhibitor and hUMSC-EVs at half doses outperformed full-dose monotherapies, accelerating wound healing through synergistic effects on collagen synthesis, cell proliferation, migration, and angiogenesis. |
| HostingRepository | iProX |
| AnnounceDate | 2025-08-18 |
| AnnouncementXML | Submission_2026-04-09_00:23:05.290.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xiaoyu Liu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF Pro |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2025-08-18 00:47:43 | ID requested | |
| ⏵ 1 | 2026-04-09 00:23:05 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: diabetes, wound healing, Cathepsin K inhibitor, mesenchymal stem cell, extracellular vesicles, ferroptosis, energy metabolism |
Contact List
| Rui Guo | |
|---|---|
| contact affiliation | Hebei University |
| contact email | rguo@hbu.edu.cn |
| lab head | |
| Xiaoyu Liu | |
| contact affiliation | Hebei University |
| contact email | 19930881189@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
