PXD067385 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Global Profiling of Human Proteome Cysteine Residues via Lipoic Acid-Mediated Disulfide Exchange |
| Description | Lipoic acid, an endogenous small molecule, is widely utilized in metabolic regulation and disease intervention. While its mechanism of action has been largely attributed to protein lipoylation, the dynamic chemical properties of its five-membered cyclic disulfide moiety remain underexplored. Here, we designed and synthesized alkyne-functionalized lipoic acid-based probes, LAN-yne and LAO-yne. Employing a chemoproteomic strategy, we systematically mapped the covalent targets of lipoic acid's disulfide bond across the cellular proteome and assessed their potential biological functions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-23 |
| AnnouncementXML | Submission_2026-05-22_20:57:59.689.xml |
| DigitalObjectIdentifier | https://doi.org/10.6019/PXD067385 |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Supported dataset by repository |
| PrimarySubmitter | Zhongyao Jiang |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | iodoacetamide derivatized residue |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-15 04:53:41 | ID requested | |
| ⏵ 1 | 2026-05-22 20:58:00 | announced | |
Publication List
Keyword List
| submitter keyword: covalent probe, cysteine, disulfide exchange, chemoproteomics,lipoic acid |
Contact List
| Zhongyao Jiang |
|---|
| contact affiliation | Shandong Normal University, Jinan 250014, P. R. China. |
| contact email | jiangzhongyao@stu.sdnu.edu.cn |
| lab head | |
| Zhongyao Jiang |
|---|
| contact affiliation | Shandong Normal University |
| contact email | jiangzhongyao@stu.sdnu.edu.cn |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067385
- Label: PRIDE project
- Name: Global Profiling of Human Proteome Cysteine Residues via Lipoic Acid-Mediated Disulfide Exchange
