PXD067299-1

PXD067299 is an original dataset announced via ProteomeXchange.

Title	Medulloblastoma LC-MS/MS using small extracellular vesicles from blood plasma, CSF, and MB cell lines
Description	Liquid biopsy is increasingly recognized for tumor diagnosis and monitoring, and in medulloblastoma (MB) and other CNS tumors, it offers the potential to bypass invasive tissue collection. However, its application in clinical practice remains limited, in part because the optimal choice of biofluid is underexplored and may differ between tumor types. Here, we report mass spectrometry–based proteomic analysis of extracellular vesicles (EVs) from three matched cerebrospinal fluid (CSF) and blood plasma (BP) samples of MB patients, alongside healthy BP controls and MB cell lines.
HostingRepository	PRIDE
AnnounceDate	2025-09-22
AnnouncementXML	Submission_2025-09-22_06:15:15.424.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Frank Stein
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-13 07:12:54	ID requested
⏵ 1	2025-09-22 06:15:15	announced

Dataset with its publication pending

submitter keyword: LC-MS/MS, medulloblastoma, medulloblastoma cell lines, blood plasma, small extracellular vesicles, CSF

Basant Kumar Thakur
contact affiliation	1)Department of Pediatrics III, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany. 2)Department of General, Visceral, Vascular and Transplant Surgery, Medical Faculty, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany.
contact email	Basant-Kumar.Thakur@uk-essen.de
lab head
Frank Stein
contact affiliation	EMBL
contact email	frank.stein@embl.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/09/PXD067299

PRIDE project URI

• PRIDE
  1. PXD067299
     1. Label: PRIDE project
     2. Name: Medulloblastoma LC-MS/MS using small extracellular vesicles from blood plasma, CSF, and MB cell lines