PXD067235 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Functional Microbial Shifts and Host-Microbiome Crosstalk in Colorectal Cancer: Evidence from a Metaproteomic Approach |
| Description | Colorectal cancer incidence is surging in many low- and middle-income countries, including Egypt, partly due to urbanization and lifestyle changes. Metaproteomics remains underutilized in such settings. This study applies a metaproteomic approach to fecal samples from Egyptian CRC patients to identify functional protein biomarkers, characterize host microbiota interactions, and uncover dysregulated metabolic pathways associated with cancer progression. Stool samples from 10 CRC patients and 10 healthy controls were analyzed. A total of 441 differentially expressed proteins (DEPs) were identified, with 406 consensus proteins intersected from fold change, Wilcoxon test, and PLS-DA analysis. COG-based enrichment revealed significant downregulation of proteins related to core microbial metabolic processes (e.g., carbohydrate, amino acid, inorganic ions and nucleotide transport). Notably, proteins from Segatella copri were markedly suppressed in CRC patients. Functional analysis revealed upregulation of microbial proteins related to DPP4 and cysteine, supporting the previous hypothesis of their translocation to the host, promoting tumor progression. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-27 |
| AnnouncementXML | Submission_2026-01-27_02:29:59.028.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Sameh Magdeldin |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion Lumos |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-11 15:44:52 | ID requested | |
| ⏵ 1 | 2026-01-27 02:29:59 | announced | |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Colorectal cancer |
| Metaproteomic |
| Microbiome |
| DPP-4 |
| Cysteine |
Contact List
| Sameh Magdeldin |
|---|
| contact affiliation | Proteomics and Metabolomics Research Program, Basic Research Unit, Research Department, Children’s Cancer Hospital Egypt 57357, Cairo, Egypt |
| contact email | sameh.magdeldin@57357.org |
| lab head | |
| Sameh Magdeldin |
|---|
| contact affiliation | Proteomics and Metabolomics Research Program, Basic Research Department, Children’s Cancer Hospital, (CCHE-57357), Cairo 57357, Egypt |
| contact email | proteomicslab2017@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
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| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067235
- Label: PRIDE project
- Name: Functional Microbial Shifts and Host-Microbiome Crosstalk in Colorectal Cancer: Evidence from a Metaproteomic Approach
