PXD067234-1

PXD067234 is an original dataset announced via ProteomeXchange.

Title	Novel Kinesin Family 1A Variants Linked to Atypical Parkinsonism Elicit Altered Neuronal TDP-43 Interactions and Dendritic Atrophy
Description	We used patient induced pluripotent stem cells (IPSC) derived neurons from a patient with two mutations in KIF1A to evaluate the quantitative changes to KIF1A protein interaction, relative to wild-type control IPSC-motor neurons, using an anti-KIF1A antibody during immunoprecipitation. Given the related findings and interests of the study, we also compared the quantitative changes to TDP-43 protein interaction, using an anti-TDP-43 antibody during immunoprecipitation.
HostingRepository	PRIDE
AnnounceDate	2025-08-26
AnnouncementXML	Submission_2025-08-26_11:01:11.074.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD067234
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Christopher Donnelly
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-11 15:43:39	ID requested
⏵ 1	2025-08-26 11:01:11	announced

10.1016/j.ajpath.2025.05.018;

10.6019/PXD067234;

Homayoun H, DeChellis-Marks MR, Kofler J, Fricklas G, Gleixner AM, Yeh FC, Lacomis D, Chu CT, Donnelly CJ, Novel Kinesin Family Member 1A Variants Linked to Atypical Parkinsonism Elicit Altered Neuronal Transactive Response DNA Binding Protein 43 kDa Interactions and Dendritic Atrophy. Am J Pathol, ():(2025) [pubmed]

submitter keyword: KIF1A,iPSC motor neurons, TDP-43

Christopher Donnelly
contact affiliation	University of Pittsburgh
contact email	cjdon25@pitt.edu
lab head
Christopher Donnelly
contact affiliation	University of Pittsburgh
contact email	cjdon25@pitt.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/08/PXD067234

PRIDE project URI

• PRIDE
  1. PXD067234
     1. Label: PRIDE project
     2. Name: Novel Kinesin Family 1A Variants Linked to Atypical Parkinsonism Elicit Altered Neuronal TDP-43 Interactions and Dendritic Atrophy