PXD067200-1

PXD067200 is an original dataset announced via ProteomeXchange.

Title	Human fingertip regeneration follows clinical phases with distinct proteomic signatures
Description	Distal injuries in human fingertips can regenerate almost fully, yet the process of human fingertip regeneration has hardly been characterized on a cellular and molecular level. A silicone finger cap, comprising a puncturable reservoir, was used to treat 22 human fingertip amputations. In all patients, subcutaneous tissue, nailbed and skin regenerated with excellent outcomes. Through the clinical assessment of the wounds, the regenerative process was divided into four distinct phases. Proteomic data from wound fluid samples collected at regular intervals, confirmed robust and unbiasedly distinct proteomic signatures, characteristic processes, and active regulatory networks in each phase. Moreover, this human dataset provides important insights, showing clear divergences from findings in regenerative animal models. The longitudinal and comprehensive analysis presented here unveils the complex orchestration of four clinically and proteomically-distinct phases of human fingertip regeneration. Further analyses of this proteomic data will allow for the identification of candidates orchestrating human fingertip regeneration and serving as a framework for comparative and regenerative medicine studies.
HostingRepository	PRIDE
AnnounceDate	2025-11-05
AnnouncementXML	Submission_2025-11-05_12:58:00.259.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Marc Gentzel
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-11 08:19:31	ID requested
⏵ 1	2025-11-05 12:58:00	announced

10.1038/S41536-025-00441-Y;

submitter keyword: Wound Regeneration, Gel-LC-MS/MS, human, Finger Tip

Tatiana Sandoval-Guzman
contact affiliation	Center for Regenerative Therapies TU Dresden, Fetscherstraße 105, 01307 Dresden, Germany
contact email	tatiana.sandoval_guzman@tu-dresden.de
lab head
Marc Gentzel
contact affiliation	Core Facility - Mass Spectrometry & Proteomics - Center for Molecular and Cellular Bioengineering (CMCB), TU Dresden
contact email	marc.gentzel@tu-dresden.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2025/11/PXD067200

PRIDE project URI

• PRIDE
  1. PXD067200
     1. Label: PRIDE project
     2. Name: Human fingertip regeneration follows clinical phases with distinct proteomic signatures