PXD067149 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic Profiling Unraveling the Role of Lactate Dehydrogenase A in Vascular Repair and Functional Recovery After Spinal Cord Injury |
| Description | This study employed label-free quantitative proteomics to profile the spinal cord tissue at multiple time points post-injury, aiming to uncover altered molecular pathways associated with endothelial cell dysfunction and repair. The proteomic analysis revealed lactate dehydrogenase A (LDHA) as a significantly upregulated protein at day post-injury 7 (DPI-7) and a potential regulator of vascular endothelial growth factor (VEGF)-VEGF receptor 2 (VEGFR2) signaling. Pharmacological inhibition of LDHA using FX-11 exacerbated oxidative stress in endothelial cells, suppressed their proliferation, hindered angiogenesis, and aggravated neurodegeneration and microglial accumulation at the lesion epicenter. These findings suggest that LDHA acts as a metabolic regulator of endothelial cell survival and angiogenic signaling under injury conditions. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-01-16 |
| AnnouncementXML | Submission_2026-01-15_23:13:33.998.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Manjeet Chopra |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-09 08:36:07 | ID requested | |
| ⏵ 1 | 2026-01-15 23:13:34 | announced | |
Publication List
Keyword List
Contact List
| Hemant Kumar |
|---|
| contact affiliation | Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad |
| contact email | hemant@niperahm.res.in |
| lab head | |
| Manjeet Chopra |
|---|
| contact affiliation | National Institute of Pharmaceutical Education and Research, Ahmedabad |
| contact email | chopramanjeet777@gmail.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/01/PXD067149 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067149
- Label: PRIDE project
- Name: Proteomic Profiling Unraveling the Role of Lactate Dehydrogenase A in Vascular Repair and Functional Recovery After Spinal Cord Injury
