PXD067094-1

PXD067094 is an original dataset announced via ProteomeXchange.

Title	Identification of RNA-binding protein interactors of duck lncrna (lnc455) using Multiple Oligo-assisted RNA Pulldown with Hybridization followed by Mass Spectrometry (MORPH-MS)
Description	This project used MORPH-MS to identify proteins that interact with a duck lncRNA called lnc455, which is linked to antiviral responses. While lnc455 was predicted to enhance RIG-I/MAVS signaling, its effects appeared to be indirect. Using MORPH-MS, we mapped the lncRNA’s binding partners and uncovered several proteins known to suppress interferon signaling. This highlights how lnc455 may support antiviral immunity by blocking these negative regulators. The study also shows how MORPH-MS can uncover RNA–protein interactions in non-model species like ducks.
HostingRepository	PRIDE
AnnounceDate	2026-04-27
AnnouncementXML	Submission_2026-04-26_16:22:59.531.xml
DigitalObjectIdentifier	https://doi.org/10.6019/PXD067094
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Renald James Legaspi
SpeciesList	scientific name: Gallus gallus (Chicken); NCBI TaxID: NEWT:9031;
ModificationList	biotinylated residue
Instrument	Orbitrap Exploris 480

Revision	Datetime	Status	ChangeLog Entry
0	2025-08-07 13:30:01	ID requested
⏵ 1	2026-04-26 16:23:00	announced

Legaspi RJ, Magor KE, Duck lncRNA lnc455 enhances RIG-I/MAVS type I interferon signaling by modulating hnRNPAB-mediated regulation of MAVS signaling. Sci Rep, 16(1):(2026) [pubmed]

10.6019/PXD067094;

10.1038/s41598-026-42849-6;

submitter keyword: MORPH-MS, Type I IFN, duck,lncrna

Katharine Edens Magor
contact affiliation	1 Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada 2 Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada
contact email	kmagor@ualberta.ca
lab head
Renald James Legaspi
contact affiliation	University of Alberta
contact email	renaldja@ualberta.ca
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/04/PXD067094

PRIDE project URI

• PRIDE
  1. PXD067094
     1. Label: PRIDE project
     2. Name: Identification of RNA-binding protein interactors of duck lncrna (lnc455) using Multiple Oligo-assisted RNA Pulldown with Hybridization followed by Mass Spectrometry (MORPH-MS)