PXD067059 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic analysis of ANO10 SH-SY5Y mutant cell lines |
| Description | To investigate the effects of ANO10 pathogenic variants in cell proteome, four SH-SY5Y mutant cell lines (a knockout cell line,and three lines bearing the following variants: ANO10 c.289delA, ANO10 c.1009T>G, and ANO10 c.1529T>G) were engineered via CRISPR-Cas9 editing. After establishment and characterisation, the cell lines were subjected to nanoLC-MS/MS proteomic analysis. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-06_16:47:14.519.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Frank Stein |
| SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: NEWT:9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Exploris 480 |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-07 05:44:27 | ID requested | |
| ⏵ 1 | 2026-09-06 16:47:15 | announced | |
Publication List
| Chrysanthou A, Ververis A, Patsali P, O'Mahony DG, Lederer CW, Christodoulou K, Proteomic profiling of ANO10-deficient SH-SY5Y cells reveals candidate pathways relevant to SCAR10. Sci Rep, 16(1):(2026) [pubmed] |
| 10.1038/s41598-026-52014-8; |
Keyword List
| submitter keyword: LC-MS/MS, ANO10, SH-SY5Y |
Contact List
| Kyproula Christodoulou |
|---|
| contact affiliation | Neurogenetics Department The Cyprus Institute of Neurology and Genetics 2371 Nicosia Cyprus |
| contact email | roula@cing.ac.cy |
| lab head | |
| Frank Stein |
|---|
| contact affiliation | EMBL |
| contact email | frank.stein@embl.de |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/09/PXD067059 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD067059
- Label: PRIDE project
- Name: Proteomic analysis of ANO10 SH-SY5Y mutant cell lines
