PXD066926 is an
original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Region-resolved proteomic analysis of mouse heart from different age groups |
| Description | Aging is a major risk factor for cardiovascular diseases (CVDs), primarily due to its association with declining cardiac function, which significantly influences the pathogenesis of conditions like myocardial infarction and heart failure. While several cardiac proteomic atlases exist, spatially resolved proteomic dynamics essential for understanding region-specific cardiac aging mechanisms remain poorly characterized. This study establishes a spatially resolved quantitative proteomic atlas across multiple murine cardiac regions at three aging stages (3, 12, and 20 months). Using bioinformatics deconvolution and machine learning, we systematically identified key cardiac aging regulators from 6,650 quantified proteins. Collectively, this work provides an extensive region-resolved proteomic landscape of cardiac aging, identifies key protein regulators, and uncovers potential targets for cardio-protective interventions against age-related CVDs. |
| HostingRepository | PRIDE |
| AnnounceDate | 2026-05-22 |
| AnnouncementXML | Submission_2026-05-22_02:07:42.426.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Lingyun Dai |
| SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: NEWT:10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Eclipse |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|
| 0 | 2025-08-04 06:12:36 | ID requested | |
| ⏵ 1 | 2026-05-22 02:07:42 | announced | |
Publication List
Keyword List
| submitter keyword: Cardiac aging |
| Region-resolved proteomics |
| Senescence |
| FTL1 |
| SERPINA3K |
Contact List
| Lingyun Dai |
|---|
| contact affiliation | Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Center, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China |
| contact email | lingyun.dai@outlook.com |
| lab head | |
| Lingyun Dai |
|---|
| contact affiliation | School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China |
| contact email | lingyun.dai@outlook.com |
| dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2026/05/PXD066926 |
| PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD066926
- Label: PRIDE project
- Name: Region-resolved proteomic analysis of mouse heart from different age groups
